Vacuum errors on your MicroCal ITC can be frustrating—but they’re often easy to resolve with a few simple checks. In this tip, we walk through a daily troubleshooting checklist: from checking liquid levels and tubing connections to inspecting the syringe and fill port adapter. Keep your ITC running smoothly with these practical steps.
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A well-maintained ITC system ensures reliable results and longer instrument life. In this tip, learn how to clean the cell and syringe after experiments, perform weekly detergent soaks, and refill the reference cell. We also cover monthly checks like plunger tip replacement. Follow these routines to keep your MicroCal ITC in top condition.
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The plunger tip in your MicroCal ITC syringe plays a crucial role in injection accuracy and data reproducibility. In this tip, learn how to recognize when it’s time to replace the plunger tip, how it affects your data, and how to do the replacement yourself using the guided software. A small part with a big impact!
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Proper cell loading is essential for high-quality ITC data. In this tip, learn techniques to avoid bubbles, especially when working with foamy or high-concentration protein solutions. Discover how to improve your technique, use built-in training videos, and even learn from colleagues or your local application scientist to ensure consistent results.
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Before starting your experiments, it’s important to verify your ITC system is performing optimally. In this tip, learn how to run a water-water test to assess cleanliness, temperature stability, and baseline behaviour. We also cover how to use the EDTA test kit for training and validation. Ensure your system is ready for your valuable samples.
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Keeping your ITC cells clean and wet is key to maintaining system performance. In this tip, learn how to store cells between experiments, including using ethanol to prevent bacterial growth. If long-term storage or shipping is needed, follow the drying protocol using methanol and gentle heating. Protect your instrument with proper care.
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Whether you’re new to ITC or training a colleague, Malvern Panalytical offers a wealth of resources to support your journey. In this tip, discover where to find webinars, application notes, white papers, technical guides, and customer Q&As. Visit our website and blog to stay informed and make the most of your MicroCal ITC system.
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